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CRC Directors
Dan
Blazer, M.D., Ph.D., Director/Principal Investigator, 1984-1992
Bernard
J. Carroll, M.B., Ph.D., Director/Principal Investigator, 1992-1998
Ranga
R. Krishnan, M.B., Ch.B., Director/Principal Investigator,
1998-
The National Institute of Mental Health’s
Clinical Research Center is a longitudinal, naturalistic study of depression
in late life. Currently
(10/20/99), the study has enrolled 260 depressed patients and 130
non-depressed controls. The
patients receive 5 years of follow-up care from one of our four research
psychiatrists (Dr. David Steffens, Dr. Ken Gersing, Dr. Kishore Gadde, and Dr.
John Beyer), biannual MRI’s, yearly neuropsychological testing, and yearly
psychosocial interviews (Duke Depression Evaluation Schedule).
The patients come in once every three months for medication management
visits. Patients are also offered
entrance into the DBT group (link). The
research controls come in once a year and get administered the DDES and the
neuropsychological battery yearly, and the MRI biannually.
Patients
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1.
60 or older
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2.
Currently diagnosed with major depression (by DSMIV standards)
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3.
Willing and able (no metallic contraindications) to have a brain
MRI
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4.
Have never had a stroke, Parkinson’s disease, Alzheimer’s, or
any other serious neurological or psychiatric diagnosis.
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5.
Do not have current drug or alcohol abuse.
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6.
MMSE score of 25 or above at baseline.
Controls
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1.
60 or older
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2.
Never been diagnosed with depression or treated for any
psychiatric illness.
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3.
Willing and able (no metallic contraindications) to have a brain
MRI
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4.
Have never had a stroke, Parkinson’s disease, Alzheimer’s, or
any other serious neurological or psychiatric diagnosis.
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5.
Do not have current drug or alcohol abuse.
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6.
MMSE score of 25 or above at baseline.
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Clinical Trials
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Imaging
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Publications
(CRC home page is under
development)
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