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Consulting
Services 

Ambulatory Blood
Pressure (ABP) Monitoring
ABP Monitors: Blood
pressure monitoring during routine daily activities is performed using the
Suntech AccuTracker II, a computer-based monitor with established validity
and reliability.
Assessments: Typical
monitoring is for a 24-hour period on a workday, with four readings/hour
while awake and two/hour while asleep.
Utility: Ambulatory
blood pressure monitoring provides unique information that is valuable for
a variety of clinical and research settings, including: diagnosis of
hypertension; evaluation of white coat hypertension, evaluation of the
efficacy of blood pressure medications; clinical evaluation of the
effective duration of antihypertensive medications; assessment of the
effects of specific daily work/home activities on blood pressure.
For further information:
Contact Andrew Sherwood
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Goals: Diagnosis of psychopathology, personality disorders, and neuropsychological deficits
including assessment of depression, anxiety, Type A behavior, memory disturbances, eating
disorders, etc.
Candidates: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: Interview and psychological testing using standardized psychometric instruments
(e.g., MMPI, SCL-90, Beck Depression Inventory, JAS etc.), projective testing (e.g., TAT,
Rorschach, etc.), and neuropsychological measures (Reitan-Halstead Battery) is available.
Patients will meet with a clinical psychologist for one or more diagnostic interview and testing
sessions. Comprehensive reports will be provided to the referring physician.
For further information, contact James A. Blumenthal, PhD at (919) 684-3828.
For more information, contact Mike Babyak, PhD at (919) 684-3828.
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Overview: In mental stress testing, patients/volunteers are exposed to a variety of mental challenges in a controlled laboratory environment, while their behavioral and physiological responses are closely monitored and recorded.
Stressors: Examples of our established mental stress tests include: public speaking, mental arithmetic, reaction time, reverse mirror tracing, anger interview.
Facility: Our test facilities include acoustic chambers, which provide a quiet, electrically-shielded and temperature-regulated environment.
Measurements: Our current facility permits monitoring of blood pressure, heart rate, heart contractility, stroke volume, cardiac output, systemic vascular resistance, plasma epinephrine, norepinephrine and cortisol responses during mental stress.
Utility: Mental stress is often associated with pronounced physiological
activation. Individuals differ markedly in their cardiovascular responses
during mental stress. For example, heart rate responses may range from no
discernible change to increases of over 100 bpm. Studies of cardiovascular
responses during stress suggest that hyperreactivity is linked to the development
of cardiovascular disease. Physiological responses during stress also provide
objective assessment of a patient's stress response, permitting evaluation of
treatment effects on stress. Stress response physiology is also a useful tool
for evaluating autonomic nervous system function.
For further information: Contact Andrew Sherwood
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Goals: This program is designed to help participants cope with life stress, chronic illness,
problems in living, and more severe psychological disorders such as major depression, post-traumatic stress disorder, etc.
Candidates: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: Participants will be assigned to an individual therapist based on presenting issues.
Participants will meet regularly with the therapist who will provide supportive therapy and/or
more structured services, depending on participant needs. Participants will learn to recognize
maladaptive behavior patterns, and will be assisted in learning how to implement strategies for
behavior change.
For more information, contact Mike Babyak, PhD at (919) 684-3828.
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Goals: This program is designed to help participants learn to manage reactions to stress. It is
particularly appropriate for persons with high levels of stress, “Type A personalities,” and patients
at risk for heart disease, although it will be useful for all participants who want to learn how to
decrease the stress in their lives.
Candidates: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: This program consists individual and group training in stress management techniques.
The group consists of a series of 16 1.5 hour sessions. Initial sessions include discussion about
the role of stress in the development of coronary heart disease. Later sessions involve instruction
in specific skills to reduce the affective, behavioral, cognitive, and physiologic components of
stress. This program can also be offered individually.
For more information, contact James A. Blumenthal, PhD at (919) 684-3828.
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Relaxation Training and
Biofeedback
Goals: This program is designed to help participants master deep muscle relaxation and gain
control over physiological responses to stress and pain. The program is useful for persons with
chronic and acute anxiety problems, Type A behavior, cardiovascular conditions such as
hypertension, and pain, including headaches.
Entry Criteria: Physician referral, Self-referral
Program: Participants will work one-on-one with a trained staff member who will provide
instruction in progressive muscle relaxation techniques and biofeedback using specialized
equipment. Participants will learn skills to help them identify and alter physiologic responses to
stress and pain both in the laboratory and at home.
For more information, contact James A. Blumenthal, PhD at (919) 684-3828.
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Weight Loss Counseling
Goals: This program is designed to help participants implement behavioral strategies to lose
weight.
Candidates: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: This is an individually tailored program based upon behavioral weight loss principles.
Participants will meet with a clinical psychologist who will help the patient identify psychological
and behavioral barriers to weight loss. Participants will work with the psychologist to develop
and implement a individualized plan for behavior change. This program serves as an adjunct to
nutritional and medical services.
For more information, contact James A. Blumenthal, Ph.D. at (919) 684-3828
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Health Psychology Classes
Goals: This is an 8-hour experiential seminar that will help participants
better understand individual stress reactions, develop coping skills to
handle stress, examine priorities, and set and achieve health and quality-of-life goals.
Entry Criteria: Physician referral, Self-referral
Program: This 8-hour class covers stress management, coping skills reducing
unwanted aspects of Type A behavior, breaking habits, improving
communication skills, examining priorites, and setting/achieving health and
quality-of-life goals.
For more information, contact James A. Blumenthal Ph.D. at
(919) 684-3828
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Goals: This program is designed to help couples who are in distressed or “self-defeating”
relationships. Relationship enhancement counseling is also available for those couples who want
to strengthen a generally positive relationship. The program is also appropriate for couples who
are learning how to adjust to chronic illness in one partner.
Candidates:: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: Participants will have weekly meetings with a
clinical psychologist who will assist the couple in learning communication
skills to improve the quality of their relationship. Examples of
skills emphasized in therapy include effective methods of expressing thoughts
and feelings and problem-solving techniques. The therapist serves as a
facilitator to help the couple develop tools that can be used to solve a
variety of relationship problems.
For more information,
Contact Jennifer Norten, PhD at (919) 684-3828
Couples Retreat
Goals: This program is designed to help couples learn positive
communication skills to improve the quality of their relationship. Couples with
a variety of presenting issues (e.g. chronic illness in one partner, general
relationship distress, pre-marital concerns, etc) will benefit from this
program.
Candidates:: Program and non-program participants; persons in
pre-marital, early marriage, or long-term relationships.
Entry Criteria: Physician referral, Self-referral
Program: This weekend program includes informational lectures
and experiential exercises designed to help couples identify problematic areas
of their relationship and develop coping skills for resolving difficulties.
Three different programs are available. One program will focus on
problems that are common in couples dealing with chronic illness - e.g.
adjusting to the partner’s physical limitations, new roles in the family, and
re-defining intimacy. A second program will focus on helping couples cope with
general relationship distress and dissatisfaction. The third
program will emphasize relationship enhancement skills.
For more information, contact Jennifer Norten, Ph.D. at (919) 684-3828
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Goals: The program is designed to help executives improve their
ability to manage stress, improve work performance, and to create a work
environment that enhances employee satisfaction and productivity.
Candidates:: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: Participants will learn to identify and reduce
nonproductive stress. The program is designed to help executives improve
communication skills, break unwanted and unproductive work habits, learn
relaxation techniques, examine and formulate realistic priorities and goals,
increase productivity, and achieve a balance between personal and professional
demands.
For more information, contact James A. Blumenthal, PhD at (919) 684-3828
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Smoking Cessation Counseling
Goals: For the person who wishes to stop smoking, this program
will assist the participant in breaking the nicotine addiction decisively and
developing a healthier overall lifestyle.
Candidates:: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: The program begins with an intensive assessment
interview with Dr. Herman, who reviews the participant’s smoking habit and
identifies factors critical in accomplishing permanent smoking cessation.
An individually-tailored cessation plan is then implemented, which may
include nicotine replacement and/or pharmacotherapy, self hypnosis or
relaxation training, lifestyle modifications, and other appropriate
interventions.
For more information, contact Steve Herman, Ph.D. at (919) 684-6475
Smoking Cessation Retreat
Goals: To enable participants to stop smoking completely and
permanently. The intensive structure of the retreat is designed for heavily
addicted smokers who have had little or no success in previous attempts to
quit smoking.
Candidates:: Program and non-program participants who are
currently smoking and who have been unsuccessful in previous attempts to stop
smoking. Participants who suffer from smoking related disorders (especially
cardiac and pulmonary conditions) are particularly encouraged to attend.
Entry Criteria: Physician referral, Self-referral
Program: Participants will undergo an intensive medical and
psychological evaluation, including an exercise stress test. Participants will
receive a combination of pharmacologic and behavioral interventions to minimize
unpleasant withdrawal side effects. Special training in stress management
techniques will be provided and weight control issues will be addressed through
a combination of nutritional education, exercise, and behavior modification.
For more information, contact Steve Herman, Ph.D. at (919) 684-6475
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Consultation is available for design and analysis in the following areas:
Design and Planning
Selecting appropriate measures
Choosing the best analytic methods
Preparation of raw data
Interpretation of existing analyses
Software recommendations for your own analyses
Power analysis
Analysis
ANOVA, ANCOVA, MANOVA, MANCOVA
Discriminant function and canonical correlation analysis
Factor analysis
Multiple linear regression
Logistic regression
Survival analysis
Structural equation modeling
Confirmatory factor analysis
Path analysis
Full latent variable models
Multi-group analysis
Partial least squares modeling (soft-modeling)
Latent growth curve models
Mixed models (hierarchical linear models or random coefficient regression)
Case-crossover analysis
For further information: Contact Michael Babyak
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Anger Management
Goals: This program is designed to help participants recognize, evaluate, and learn strategies to
reduce their anger and hostility.
Candidates: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: This 6-session workshop is based upon the best-selling book Anger Kills by Redford
and Virginia Williams. The workshop teaches participants techniques to identify, evaluate, and
reduce anger. The workshop is designed to reduce the number of occasions that anger occurs,
teach different response options to anger, and to improve the overall quality of relationships.
For more information, contact James Blumenthal, PhD at (919)
684-3828.
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Noninvasive Measurements
Blood Pressure
Blood pressure monitoring capabilities include:
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Standard stethoscopic procedure
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Automated auscultatory using R-wave gating
(Suntech 4240 suitable for
measurement during exercise testing
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24-hour ambulatory monitoring during typical daily activities
(AccuTracker II)
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Automated oscillometric measurement
(Dinamap, Omron)
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Continuous finger blood pressure
(Finapres 2400)
Impedance
Cardiography
Impedance cardiography presents a noninvasive method of measuring cardiac
output and contractility using disposable chest electrodes which measure
electrical bioimpedance. With concurrent blood pressure measurement,
impedance cardiography provides continuous assessment of:
Heart Rate Variability
Heart rate variability is assessed on the basis of ECG R-wave interval
analysis during spontaneous breathing and paced respiration. A second
procedure involves use of the Finapres to simultaneously record beat-by-beat
interbeat interval and blood pressure. These techniques provide the basis
for spectral and/or sequence analysis to generate a number of indices of
autonomic function, including:
Vascular Structure
Strain gauge plethysmography is used to measure forearm blood flow. This
measurement is taken while the forearm tissue is ischemis, following 10
minutes of forearm exercise while blood flow to the forearm is completely
occluded by a tourniquet. By measuring blood flow and blood pressure
simultaneously, minimal forearm vascular resistance (MFVR) is derived. The
MFVR measure is a validated index of vascular hypertrophy, making MFVR a
useful measurement if the assessment of hypertensive vascular disease.
For further information: Contact Andrew Sherwood
Invasive Measurements
Plasma Catecholamines
The optimal methodology for drawing blood for assessment of plasma
epinephrine and norepinephrine under different behavioral conditions it to
take an integrated sample over the period of interest. Our sampling
procedure involves the insertion of a cannula into a forearm vein. The
cannula is connected by heparin-treated polyehylene tubing to a blood
withdrawal pump (Cormed ML6 continuous blood withdrawal system). Blood is
collected in Ethylenediaminetetraacetic acid (EDTA) teated sample-tubes at a
rate of 2 ml/min. Samples are immediately cold-centrifuged and the plasma
pipetted and frozen at -80C until the time of HPLC assay.
B-adrenergic Receptor Responsiveness
The standardized isoproterenol sensitivity test is used to evaluate B-adrenergic receptor responsiveness. This test has been widely used since
1972 and its safety and reliability have been well proven. It is through the use of
this test that studies indicate that there is a progressive impairment of
B-sensitivity in human hypertension.
This test involves the intravenous infusion of progressively increasing
bolus doses of isoproterenol until a criterion response is observed. The
target response is to produce an increase in heart rate of 25 bpm, assessed
on the basis of the shortest three-successive ECG R-R intervals following
drug injection, compared to the shortest three R-R intervals at rest
(pre-injection).
A-Adrenergic Receptor Responsiveness
The procedure used for assessing A-adrenergic responsiveness is analogous to
the B-responsiveness test described above, but this time using the Ax
agonist phenylephrine, to stimulate vascular A1 receptors. In this test,
criterion response is represented by a dose which raises mean arterial
pressure by 25 mmHg (PD25). We have found PD25 responses to indicated
significantly greater A1 sensitivity in African Americans compared to
Caucasians, suggesting that A-adrenergic receptor function may be related to
the higher prevalence of hypertension in African Americans.
Baroreceptor Reflex Function
Gain of the baroreceptor system is derived from the slope of the peak
changes in cardiac interbeat interval (IBI) associated with peak change in
blood pressure in response to bolus doses of phenylephrine (see A-adrenergic
receptor responsiveness procedure). This procedure is a widely used and
validated technique for measuring baroreceptor gain. Our studies indicate
that noninvasive estimates of baroreceptor function, using continuous blood
pressure and IBI data, provide comparable information to the phenylephrine
procedure.
For further information: Contact Andrew Sherwood
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Sexual Dysfunction Counseling
Goals: This program is designed to help participants cope with
sexual problems such as erectile dysfunction, premature ejaculation, low sexual
desire, orgasmic difficulties, etc.
Candidates:: Program and non-program participants
Entry Criteria: Physician referral, Self-referral
Program: Participants will meet with a clinical psychologist
who will assist patients in identifying and modifying physical, psychological,
and relationship factors contributing to sexual dysfunction and/or
dissatisfaction. When indicated, referral to appropriate medical subspecialties
including urology, endocrinology, and gynecology will be expedited. Treatment
may involve work with the participants sexual partner, as well as individual
counseling.
For more information, contact Steve Herman, PhD at (919) 684-6475
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