CRIS

 SSRI's

Serotonin-Specific Re-uptake Inhibitors (SSRI’s)

I. PURPOSE
The SSRI (selective serotonin reuptake inhibitor) antidepressants increase the serotonergic function in the brain. These medications are generally effective in the treatment of depression. Therapeutic benefits can also be observed in the reduction of panic symptoms, control of obsessive‑compulsive symptoms and anger management.

II. SPECIFIC MEDICATIONS

• Prozac (fluoxetine)

• Paxil (paroxatine)

• Zoloft (sertraline)

• Celexa (citalopram)

• Luvox (fluvoxamine)

• Lexapro (ecitalopram)

III. SIDE EFFECTS AND OTHER IMPORTANT INFORMATION
Most commonly observed side effects include anxiety, agitation, nervousness, insomnia or somnolence, tremors, sweating, nausea, vomiting, diarrhea, dizziness and headache. Decreased appetite and sexual disturbances (decrease libido, anorgasmia, impotence) may occur.

Rash, and, at times, more serious skin reactions can be observed. Rarely, hyponatremia (low blood salt) may develop with an increase in thirst, increase in urine volume, and mental confusion.

Report any side effects to your therapist and physician. If you have a severe reaction go to Emergency Services (911) or to your local Emergency Department 

These medications may lower the seizure threshold. Inform your doctor if you have epilepsy or liver disease, or if you are or intend to become pregnant. 

SSRI antidepressants should not be used together with MAOI antidepressants, tryptophan or

Seligine (Eldepril).   Life threatening reactions may occur.  SSRIs may disrupt the anticoagulant effects of blood thinners (Warfarin: Coumadin) and increase the level of tricyclic antidepressants (Imipramine, Nortriptyline, etc.). These medications, especially Luvox, may alter the blood level of many drugs (Benzodiazepines, Theophyline, Propanolol, etc.). Seldane (Terfenadine), Hismanal (Astemizole) and Propulsid (Cisapride) should not be taken with Luvox. Serious cardiac disturbances may develop.

Inform all of your physicians of your treatment with this medication, and report every drug you are taking. Check with the pharmacist before taking any over‑the‑counter medication or natural herb preparations (St. John's Wort and others).  These medications should be stored in a cool, dry place. If you miss a dose, do not take extra amounts of medication, 

COMMENTS:                                                                                              

IV. By signing, I acknowledge receiving this medication information and verbal explanations.

Client Responsible Person                                            Date                         

Physician/Therapist                                                     Date                          

Gratefully acknowledge Wake County Human Services Staff Psychiatrists who have generously given us permission adapt their original patient education material

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