Location of WMH and Alterations in White Matter Tracts in Late Onset Depression

Principal Investigator - Ranga Krishnan, M.D.
Neuropsychiatric Imaging Research Laboratory - NIRL

The primary aim of this project is to evaluate the impact of medial orbital prefrontal cortex lesions and basal ganglia lesions on brain regions critical to the mood circuit. This project will shed light on the nature and location of some of the disruptions of the circuits described earlier. The information from this project is critical for all other projects and will be needed to understand results from the other projects. This project will lead to significant innovation in the development of new imaging techniques and assessment tools. The results of the project should greatly aid our understanding of the neuroanatomical substrates of depression. This project will identify patients for subsequent post mortem studies in project 2 and be the source of subjects for project 3 and 5.

Discussion

Revised: January 03, 2006

DISCLAIMER
You have entered a web site that describes an NIMH-funded collaborative study on the neurobiological mechanism of depression. If you are seeking immediate help for treatment of depression, we recommend that you contact your clinician or your nearest emergency room. This web site is not set up to provide help or advice to individuals about their depression, nor to family members or friends of individuals with depression. This web site is created for the purposes of providing background information about the study and having researchers provide input to the design. If you are interested in getting general information about depression, you can visit the following web site: www.nimh.nih.gov/publicat/depressionmenu.cfm