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CNSCR Studies Overview
Researchers at the Center conduct studies examining a wide variety of
issues related to smoking. Descriptions of the studies for which we are
currently seeking participants can be found below. Some studies are for
subjects that want to quit smoking, while others are for subjects that
might not be ready to quit.
Please
read through the descriptions carefully. If you are interested in
participating in one of the projects, please contact the person listed
in the study description.
Please
Note: women who are pregnant or nursing cannot participate in our
studies, and women of childbearing potential must avoid becoming
pregnant during the course of a study. If you are a woman of
childbearing potential, a blood pregnancy test will be done (using about
one teaspoon of blood drawn from a vein), and it must be negative before
you can enter a study.
CURRENT STUDIES
Quit
Smoking Studies
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Concurrent Nicotine Patch/ Denicotinized Cigarette Therapy for Smoking
Cessation II (Durham,
Raleigh and Winston-Salem locations)
Laboratory
Studies
•
Comparison of Chippers and Addicted Smokers in Compensatory Behavior in
Response to Nicotine Deprivation
(Raleigh and Winston Salem locations)
Concurrent Nicotine Patch/ Denicotinized Cigarette Therapy for Smoking
Cessation II
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The purpose of this study is to
assess the value of nicotine patch therapy in combination with
nicotine-free cigarettes as a step toward quitting smoking
successfully. Conventional FDA approved nicotine patches will be
used.
This study consists of 1 physical
screen and 7 visits over a 12 week period. The physical will
take approximately 2-2½ hours and includes a drug screen. If you
test positive for illegal drugs you will not be eligible to
participate. The 7 visits will each last approximately 45
minutes and will take place between 9AM and 5PM Monday through
Friday. If you complete all laboratory visits you will be
compensated up to $140.
If you pass the physical screen, we
will ask you to come in for your 1st visit about 5-7 days later.
At this visit you will receive a supply of nicotine patches and
cigarettes without nicotine. You will be asked to only use our
supplies for the next two weeks. You will also be asked to set
your quit smoking date 2 weeks from the date of your 1st visit.
After your quit date, you will
continue to wear the study nicotine patches but not smoke any
type of cigarette. After 6 weeks we will gradually lower your
nicotine patch dosage.
All seven study visits will have
the same format. We will measure the carbon monoxide in your
breath, collect a saliva sample and take your heart rate and
blood pressure.
For further information or to
participate in this study, please call 888-525-DUKE, or e-mail
smoking@duke.edu
IRB#
1223 |
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Comparison of Chippers and Addicted Smokers in Compensatory Behavior in
Response to Nicotine Deprivation
The purpose of this study is to examine
responses to nicotine and to the drug mecamylamine in chippers
(occasional, non-dependent smokers) and in dependent smokers.
Conventional nicotine patches will be used in the study.
We will recruit healthy males and
non-pregnant females, ages 18 - 65 years, from the Raleigh and
Winston-Salem communities for this study.
If you agree to participate in this study
you will first come in for a screening visit. You will be given a
physical examination to be sure you will not be put at any risk by being
in this study. We will monitor your heart rate and blood pressure. We
will draw a sample of about 2 tablespoons (30ml) of blood from a vein in
your arm and we will collect a urine sample. You will also smoke one
cigarette through a smoking device. This visit will last approximately 2
hours.
This study requires a total of 5 visits (1
screening and 4 laboratory visits). Subjects will be asked to not smoke
for 12 hours prior to each laboratory session. During each lab visit we
will collect one saliva sample and multiple small blood samples, take
carbon monoxide readings, and participants will fill out multiple
questionnaires. Subjects will apply a skin patch (Nicoderm 21 mg/24 h or
placebo) and subjects will swallow one capsule containing mecamylamine
or placebo. Subjects will also smoke through a device which mixes
together smoke from two cigarettes and have a 1 hour period of ad-lib
smoking. Each lab visit will last 4.5 to 5 hours.
There is no cost to you to participate in
this study. Any costs, including study procedures and supplies, will be
paid for by the study.
Subjects will be paid up to $400 for
completing this study. Subjects will not be compensated for the
screening.
For further information or to participate
in this study, please call 888-525-DUKE,
or e-mail
smoking@duke.edu
IRB# 1782
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